PKRRATING OPTIONS

3B). R526 from your loop between αJ and αI anchors the C-terminal percentage of the activation loop by forming a salt bridge with E458 at The bottom of αEF. Q459 stabilizes the HRD motif by a hydrogen bond to the key chain carbonyl of R413. The idea with the activation segment is stabilized by a hydrogen bond in between Y454 and E480 from αF. I